SBIR/STTR Research Award
Real-time Detection of GPCR Conformational Change
Award amount
$100,000Program and phase
SBIR · Phase IAward year
2005Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- Biodesy LLC
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- X5NEJGZBNAT5
- Solicitation number
- PHS2005-2
- Topic code
- Not reported
Research abstract
DESCRIPTION (provided by applicant): A novel, optical detection system for detecting conformational change in a GPCR (G Protein-coupled receptor) has been devised. The detection system is based on second-harmonic generation, a nonlinear optical technique. Phase I specific aims are final construction, control experiments and optimization to demonstrate feasibility of the detection system. The beta-2 adrenergic receptor, a prototypical GPCR, will be the model protein for Phase I studies. Drug screening and basic scientific studies of receptor activation are the long-term objectives of the proposed detection system.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- High-throughput screening assay of GPCR drug candidates using second harmonic generation for direct detection of structural changes
- SHG based screening assay for detecting effectors of brain localized GPCRs that can be used to probe mental illness related phenotypes
- SBIR Phase II: Development of an SHG Instrument, Artemis QuantTM, for measuring conformational change in real time
- SBIR Phase I: Development of a conformational screen for rapidly identifying kinase inhibitor type using SHG
- SHG for Integrin receptor drug discovery
Research funding history
6 SBIR/STTR records share this UEI (2005–2019). Reported award amounts total $1,663,757. Reported amounts are not federal obligations.
Phases: Phase I, Phase II
Agencies: Department of Health and Human Services, National Science Foundation