SBIR/STTR Research Award

Multiplex polony genotyping

Award identifier cfc78991bb4cdaeebafe942b8ab9e290e853b4a0b27d89abdd08a10f064a223dAwarding agency Department of Health and Human Services · National Institutes of Health

Award amount

$117,939

Program and phase

SBIR · Phase I

Award year

2003

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Award details

Awarding agency
Department of Health and Human Services
Branch
National Institutes of Health
Recipient company
AGENCOURT BIOSCIENCE CORPORATION
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
Not reported

Research abstract

(Revised Abstract) Description: The ascertainment of millions of SNPs in the human genome, characterization of haplotype blocks and development of improved SNP-based linkage panels has fueled the need for accurate, efficient, and low cost SNP genotyping technologies to support genetic inheritance and disease association studies. The overall goals of this proposal are to develop and test a novel method for multiplex genotyping using in-gel polony amplification and fluorescence in situ sequencing. In Phase I, the core genotyping technology will be tested using a set 372 SNPs from The SNP Consortium (TSC) linkage panel with known genotypes on individuals from the CEPH families. Genotypic data will be collected from 48 unrelated CEPH individuals and evaluated in terms of success rate and accuracy. The cost competitiveness of the technology relative to other established genotyping technologies will then be evaluated.

Technology keywords

Not reported

Agency intelligence

Department of Health and Human Services

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