SBIR/STTR Research Award
MAJOR OBJECTIVES OF THIS RESEARCH ARE TO (1) ISOLATE 100 MG OF HOMOGENEOUS DIHYDROFOLATE REDUCTASE (DHFR) FROM CANDIDA ALBICANS, (2) CRYSTALLIZE THE ENZYME, AND (3) DETERMINE ITS THREE-DIMENSIONAL STRUCTURE USING X-RAY DIFFRACTION METHODS.
Award amount
$50,000Program and phase
SBIR · Phase IAward year
1986Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- Agouron Pharmaceuticals Inc.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
MAJOR OBJECTIVES OF THIS RESEARCH ARE TO (1) ISOLATE 100 MG OF HOMOGENEOUS DIHYDROFOLATE REDUCTASE (DHFR) FROM CANDIDA ALBICANS, (2) CRYSTALLIZE THE ENZYME, AND (3) DETERMINE ITS THREE-DIMENSIONAL STRUCTURE USING X-RAY DIFFRACTION METHODS.ARMED WITH THE RESULTING DETAILED KNOWLEDGE OF THE GEOMETRICAL AND TOPOGRAPHICAL PROPERTIES OF CANDIDAS DHFR INRELATION TO THE KNOWN STRUCTURE OF THE CORRESPONDING VERTEBRATE ENZYME, AGOURON TECHNOLOGY WILL DESIGN SPECIFIC, PHARMACOLOGICALLY ACTIVE INHIBITORS THAT SELECTIVELY CRIPPLETHE BACTERIAL REDUCTASE WITHOUT INTERFERING WITH ONE-CARBON METABOLISM IN THE HOST. SUCH NOVEL INHIBITORS WILL ADDRESS THE CURRENT NEED FOR NEW ANTI-INFECTIVE AGENTS WITH ENHANCEDANTI-CANDIDAL ACTIVITY AGAINST CANDIDA ALBICANS.
Technology keywords
Not reported