SBIR/STTR Research Award
New Tools for Structural Variation Analysis, De Novo Assembly and Closing of Complex Genomes
Award amount
$224,925Program and phase
SBIR · Phase IAward year
2014Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- LUCIGEN CORPORATION
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- L9SNJEY728V3
- Solicitation number
- PA14-071
- Topic code
- NHGRI
Research abstract
DESCRIPTION (provided by applicant): Next-generation sequencing (NGS) platforms are fundamentally altering genetic and genomic research by providing massive amounts of data in a low-cost, high-throughput format. The main drawback of existing technologies is the short sequence read lengths they produce. Existing library prep methods are also constrained in producing short inserts of only a few kb. As a result, de novo assembly of genomes is not practical with short read NGS technologies alone. Even with a high quality reference human genome, resequencing and assembly of new human genomes is a significant challenge when analyzing complex genomic regions. Haplotyping across more than a few kb is not achieved without resorting to cloned DNA. New tools that bridge the gap between massively parallel short read sequencing technologies (lt1,500 bases) and the need for large scaffolds gt 20 kb to assemble a genome are clearly needed. The SBIR Phase I grant proposal New Tools for Structural Variation Analysis, De N
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Tools for Exceptional Overexpression and Structural Stabilization of Membrane Proteins in Mammalian Cells
- Rapid and Simple Device for Point-of-Care Molecular Detection of Arboviruses
- A Microfluidic System for POC Molecular Diagnosis of HPV in Oral Fluids
- Mini Chromosome and Fluorescent Proteins for Expression of Protein Complexes
- Integrated biochemical and bioinformatic technologies for accurate transcriptome-wide full-length RNA assembly.
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Platform to support clinical variant interpretation through probabilistic assessment of functional evidence
- Innovations to expand and accelerate the commercial impact of DNA modifications
- High-throughput Direct Sequencing and Quantitative Mapping of RNA Modifications using Mass Spectrometry.
- Super-resolution single-molecule sequencing by observing the dynamic hybridization of a repertoire of oligonucleotides to DNA targets
- Exhaustive de novo sequencing of every RNA in a sample by a layer-by-layer mass spectrometry ladder intensity approach.
Research funding history
51 SBIR/STTR records share this UEI (2000–2016). Reported award amounts total $23,195,889. Reported amounts are not federal obligations.
Phases: Phase I, Phase II
Agencies: Department of Health and Human Services, National Science Foundation, Department of Agriculture, Department of Energy