HISTIDINE KINASE ASSAY FOR DISCOVERY OF NEW ANTIFUNGALS

Not Available Laser weapon systems currently under development, such as the Airborne Laser (ABL), must successfully fire laser beams over long horizontal paths through the atmosphere. Pointing the laser to hit the target in this scenario requires compensation for at least three effects: 1) target motion; 2) weapon platform motion; and 3) atmospheric turbulence effects. Pointing errors arising from atmospheric turbulence effects are random, and sensing these errors poses unique difficulties. Propagation over a long path causes the atmospheric induced phase errors to be converted into amplitude errors, which we refer to as scintillation. A potential solution to the problem of target tracking under conditions of strong scintillation is to use phase unwrapping techniques to reconstruct an estimate of the phase of the incident field which accounts for the discontinuities arising from branch points. Recent work in two-dimensional phase unwrapping techniques has shown that if the aperture is appropriately sampled by a Hartmann sensor, then it is possible to reconstruct the actual phase of the incident field. Under this program we propose to implement the latest phase unwrapping and branch point reconstruction problem, and use these new approaches to determine the optimal pointing angle for a laser beam.