Source Localization Head Shapes from External Measures

Our goal is to develop external head shape/skull parameter measurement techniques which will permitconstruction of Boundary Element Method (BEM) head shape models to improve Dipole Source Localizatioprocedures, useful in analyzing brain Event-Related Potentials (ERPs) and magnetoencephalograms (MEGtechniques would make electrophysiological imaging a potentially useful research and clinical tool wwide variety of human brain functions that are testable with cognitive-based ERPs as well as with seresponses from lower brain centers. In turn, this could affect diagnosis and/or treatment evaluationin schizophrenics, depressives, drug abusers, and Alzheimer's patients, among others. The Specific Ato develop the necessary techniques for a scalp-derived headshape-model and then compare the DSL resmodel, with a gold standard model constructed when additional detail of inner surfaces from the MRIComparisons will include both simulations and analysis of evoked response data.