SBIR/STTR Research Award

TGF-Beta Antagonists to Treat Mycobacterial Infections

Award identifier 2637e845d7ea7123726636f0450fa2df0112214d0e58c73457d115552cc4cb15Awarding agency Department of Health and Human Services

Award amount

$99,960

Program and phase

SBIR · Phase I

Award year

1995

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Award details

Awarding agency
Department of Health and Human Services
Branch
Not reported
Recipient company
Corpixa Corp.
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
Not reported

Research abstract

Mycobacteria multiply in macrophages. Previous work has indicated that inhibition of TGF-beta produlimit the growth of intracellular pathogens including M. avium. This project will examine the potentantagonists to affect the growth of M. tuberculosis (Mtb) in human macrophages. Studies will includeselected antagonists in combination with cytokines and the use of antagonists in vivo to limit infecmodels of M. tuberculosis.

Technology keywords

Not reported

Agency intelligence

Department of Health and Human Services

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