THE OBJECTIVE OF THIS PROJECT IS TO SYNTHESIZE NEW GOSSYPOL DERIVATIVES FOR USE AS MALE CONTRACEPTIVES.

THE OBJECTIVE OF THIS PROJECT IS TO SYNTHESIZE NEW GOSSYPOL DERIVATIVES FOR USE AS MALE CONTRACEPTIVES. THE FACT THAT GOSSYPOL ITSELF IS ALREADY BEING USED AS A MALE CONTRA- CEPTIVE AGENT IN CHINA, AND THE NEED FOR AN INEXPENSIVE, REVERSIBLE, NONTOXIC MALE CONTRACEPTIVE IN DEVELOPING COUNTRIES INDICATES THAT NEW, MORE POTENT GOSSYPOL DERIVATIVES WILL BE COMMERCIALLY SUCCESSFUL. THE GOSSYPOL DERIVATIVES WILL BE TESTED FOR ABILITY TO INHIBIT ANDROGEN AND ESTROGEN BINDING TO PROTEINS, SPERM MOBILITY, AND SPERM METABOLISM. SUFFICIENT QUANTITIES OF THESE ANALOGUES FOR LATER IN VIVO STUDIES (PHASE II) WITH RATS AND HAMSTERS WILLPREPARED. LATER STUDIES (PHASE II) MAY ALSO INCLUDE TESTINGTHESE GOSSYPOL DERIVATIVES FOR ABILITY TO INHIBIT THE GROWTHOF TRYPANOSOMA CRUZI AND KILLING HERPES VIRUS.