SBIR/STTR Research Award

IMMUNOTOXIN THERAPY OF ALLERGY

Award identifier e47598a4f8cbaac4da5bdd614e29d084c36629de2b594d1c001c263d2cbaf9dcAwarding agency Department of Health and Human Services

Award amount

$50,000

Program and phase

SBIR · Phase I

Award year

1989

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Award details

Awarding agency
Department of Health and Human Services
Branch
Not reported
Recipient company
IMMUNETICS, INC.
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
Not reported

Research abstract

FOLLOWING ON SUCCESS IN A MURINE MODEL SYSTEM, A HUMAN IGE-SPECIFIC IMMUNOTOXIN WILL BE SYNTHESIZED AND EVALUATED FOR EFFICACY AGAINST AN IGE-SECRETING HUMAN MYELOMA CELL LINE. MONOCLONAL ANTIHUMAN IGE ANTIBODY WILL BE COVALENTLY ATTACHED TO A VARIETY OF CYTOTOXINS TO PRODUCE A HUMAN IGE-SPECIFIC IMMUNOTOXIN. THIS REAGENT WILL BE TESTED FOR SPECIFIC CYTOTOXICITY AGAINST THE HUMAN IGE MYELOMA LINE IN VITRO. THE IN VITRO-SELECTED IMMUNOTOXIN FORMULATION WILL BE EVALUATED IN VIVO BY ESTABLISHING THE MYELOMA LINE IN NU/NU MICE AND ATTEMPTING TO MODULATE HUMAN SERUM IGE LEVELS BY PARENTERAL ADMINISTRATION OF IMMUNOTOXIN. THE ULTIMATE GOAL OF THIS RESEARCH IS TO PROVIDE IMPROVED ALLERGY THERAPY VIA IGE-SPECIFIC IMMUNOTOXINS.

Technology keywords

Not reported

Agency intelligence

Department of Health and Human Services

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