SBIR/STTR Research Award
COFFEE ALPHA-GALACTOSIDASE CDNA CLONING FOR BLOOD PROCESSING
Award amount
$50,000Program and phase
SBIR · Phase IAward year
1991Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- HAWAII BIOTECH, INC.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- ECJKEEFL4L51
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
IT HAS BEEN DEMONSTRATED THAT ALPHA-GALACTOSIDASE AND ALPHA-N-ACETYL GALACTOSAMINIDASE HAVE THE ABILITY TO ENZYMATICALLY CONVERT TYPE B AND A HUMAN ERYTHROCYTES, RESPECTIVELY, TO SEROTYPICALLY TYPE O ERYTHROCYTES. THIS ABILITY WOULD OBVIATE THE NEED FOR TYPING OR CROSSMATCHING, WOULD SIMPLIFY INVENTORY IN BLOOD BANKS, AND WOULD EXPEDITE THE DELIVERY OF TRANSFUSIONS. WE WILL SYNTHESIZE AND CLONE THE CDNA ENCODING THE ALPHA-GALACTOSIDASE FOUND IN GREEN COFFEE BEANS FOR EVENTUAL PRODUCTION IN MICROBIAL EXPRESSION SYSTEMS. DURING PHASE I, THIS WILL ENTAIL IDENTIFYING A COFFEE TISSUE TO USE AS A SOURCE OF THE ALPHA-GALACTOSIDASE MRNA, CDNA SYNTHESIS AND CLONING, AND IDENTIFYING RECOMBINANT CDNA CLONES EXPRESSING PROTEIN RECOGNIZED BY ANTI-ALPHA-GALACTOSIDASE ANTISERUM.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Chikungunya Recombinant Subunit Vaccine
- Development of a Cross-Protective New World Encephalitic Alphavirus Subunit Vaccine
- Novel TLR-4 Agonists as Vaccine Adjuvants
- RECOMBINANT WEST NILE VIRUS VACCINE ADJUVANTED WITH SLA-LSQ
- Chikungunya Recombinant Subunit Vaccine
Research funding history
103 SBIR/STTR records share this UEI (1983–2024). Reported award amounts total $40,917,853. Reported amounts are not federal obligations.
Phases: Phase I, Phase II, Phase II – Direct to Phase II
Agencies: Department of Health and Human Services, Department of Defense, National Science Foundation, Department of Agriculture