SBIR/STTR Research Award

HUMAN PROTEIN DIFFERENTIAL DISPLAY ASSAY ICAT-ULC-MS/MS

Award identifier 3d5c5e3db6dfde28e3dfd128e3510b1ea607e7b109cfb6403ef4f3f7442151e2Awarding agency Department of Health and Human Services · National Institutes of Health

Award amount

$143,121

Program and phase

SBIR · Phase I

Award year

2001

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Award details

Awarding agency
Department of Health and Human Services
Branch
National Institutes of Health
Recipient company
BIOARRAY TECHNOLOGIES, INC.
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
Not reported

Research abstract

DESCRIPTION: (Applicant's description) Development and testing of a protein differential display assay system, for proteomes of higher eukaryotes, using isotope-coded affinity tags (ICAT) and microcapillary liquid chromatography tandem mass spectrometry (uLC-MS/MS), is proposed. This system includes specific immunoaffinity capture of proteins during CAT analysis. Initial Phase I studies are proposed for development and optimization of phosphotyrosine specific protein differential display assay using a well characterized phosphotyrosine specific antibody and human carcinoma cells in culture. In Phase II, assays for other cell types and tissues will be developed. In addition, subtraction of high abundant and enrichment of low abundant proteins, in crude protein extracts, will be incorporated. Phase II studies also include use of novel CATs for comprehensive analysis of post-translational modifications.ln full development, this assay system provides for comprehensive analysis of the complex proteomes such as that of human. PROPOSED COMMERCIAL APPLICATION: Not available

Technology keywords

Not reported

Agency intelligence

Department of Health and Human Services

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