SBIR/STTR Research Award
Clinical development of 18F PET tracer for imaging VEGF receptors
Award amount
$222,920Program and phase
SBIR · Phase IAward year
2014Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- SIBTECH, INC.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- MB7SNF2LNJC9
- Solicitation number
- PA13-088
- Topic code
- NCI
Research abstract
The overall goal of this collaborative Fast-Track project is clinical development of a novel 18F PET tracer for molecular imaging of receptors for vascular endothelial growth factor (VEGFR). This receptor is the major anti-angiogenic drug target in oncology patients. Critically, VEGFR prevalence decreases when VEGF/VEGFR anti-angiogenic inhibitors work , and increases when these drugs stop working . These findings provide a rationale for VEGFR imaging for image-guided anti-angiogenic therapy. To provide for high selectivity, specificity, and VEGFR-mediated intracellular accumulation, the 18F PET tracer will be targeted by VEGFR ligand, scVEGF. The protein will be site-specifically derivatized with a strained alkyne for copper-free click- chemistry radiolabeling with 18F-PEG(4)-azide. In Phase I of this project we will select the lead scVEGF/Alkyne conjugate, optimize conditions for 18F radiolabeling, and validate the use of lead tracer for monitoring anti- angiogenic therapy in a murine model of triple neg
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Topic 375: 18F PET Tracer For Imaging PD-L1 (Moonshot)
- SYSTEMIC RADIONUCLIDE THERAPY TARGETED TO VEGF RECEPTORS IN TUMOR VASCULATURE
- Targeted drug delivery to tumor microenvironment
- Clinical development of 18F PET tracer for imaging VEGF receptors
- SBIR TOPIC 85 PHASE I, DEVELOPMENT OF MOLECULAR IMAGING AGENTS AND METHODS TO DETECT HIGH RISK ATHEROSCLEROTIC PLAQUE 9/8/2014 - 9/7/2015
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Mini-reflectance confocal microscope (Mini-RCM) for aiding skin cancer diagnosis and treatment
- Development of small molecule therapeutics targeting AR-V7 for prostate cancer
- Decentralized Clinical Trial of Effectiveness of EnergyPoints App to Guide Acupressure Use for Fatigue and Sleep Disturbances in Cancer Survivors
- Optimized targeted radiotherapy of pancreatic cancer
- Adaptive imaging for pioneering multiplexed spatial profiling of tumors and tissues for cancer research and diagnosis
Research funding history
31 SBIR/STTR records share this UEI (1996–2018). Reported award amounts total $10,831,410. Reported amounts are not federal obligations.
Phases: Phase I, Phase II
Agencies: Department of Health and Human Services, Department of Energy, Department of Defense