SBIR/STTR Research Award
THE DEVELOPMENT OF HUMAN ANTIBODIES AGAINST RICIN BY INVITOR STIMULATION
Award amount
$64,212Program and phase
SBIR · Phase IAward year
1990Award details
- Awarding agency
- Department of Defense
- Branch
- Army
- Recipient company
- Univax Biologics, Inc.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
THIS SBIR PROPOSAL DESCRIBES THE DEVELOPMENT OF AN APPROACH TO IMMUNOPROPHYLAXIS AGAINST RICIN TOXIN. WE PLAN TO PRODUCE A RICIN TOXOID VACCINE FOR THE DEVELOPMENT OF HUMAN MONOCLONAL ANTIBODIES AGAINST RICIN TOXIN. IN PHASE I, WE PROPOSE TO PRODUCE AND CHARACTERIE A CANDIDATE RICIN TOXOID VACCINE AND USE THIS VACCINE FOR INVITRO SIMULATION OF HUMAN LYMPHOCYTES THE SECRETE ANTIBODIES AGAINST RICIN TOXIN. IN PHASE II, HUMAN HYBRIDOMAS SECRETING MONOCLONAL ANTIBODIES AGAINST RICIN TOXIN WOULD BE PRODUCED BY FUSING EBV-TRANSFORMED LYMPHOCYTES TO THE HETEROMYELOMA FUSION PARTNER SHM-D33. NEUTRALIZING MONOCLONAL ANTIBODIES ARE EXPECTED TO BE USEFUL FOR BOTH THE PROPHYLAXIS AND THERAPY OF RICIN POISONING.
Technology keywords
Not reported