Microfluidic Array Biosensor

In response to CBD need, Physical Optics Corporation (POC) proposes to develop and fabricate a novel Microfluidic Array Biosensor (MICAB) as a new, sensitive, simple-to-use, hybrid instrument system for the early and rapid detection of environmentalbacterial and viral pathogens. The concept of the system is based on the combination of microfluidics and evanescent wave phenomena. The MICAB will consist of three elements: a 3D capillary array, a backlit diffuser screen, and a processing/analyzingsubsystem. The device will significantly enhance the operational efficiency and readiness of shipboard, land-based, and expeditionary naval forces. In Phase I, POC will demonstrate the feasibility of the MICAB device for rapid and extremely sensitivedetection of pathogens in liquid. Phase II development will culminate in fabrication and validation of MICAB system incorporating an array of molecular markers (100 and more) for rapid and reliable detection of multiple food and water pathogens byuntrained personnel. The successful completion of this project will result in a sensitive, reliable, easy-to-use and cost-efficient food and water pathogen detection device. Other potential applications include food industry; medical diagnostics ofpathogens as well as immunoassay for hormones, medications, and metabolites; wastewater treatment facilities; pharmaceutical industries; and environmental monitoring and industrial safety.