Automated Preferential Display for the Analysis of Gene Expression Profiles

"GeneXpress Informatics, Inc. (GXI) and Dr. James P. Chambers of UTSA propose to develop a revolutionary differential gene display technology, called Preferential Display (PD) which will provide for a simplified, cost-effective method to identify thesegenes for use in discovering gene expression profiles without having any prior knowledge of an organism, tissue or biological samples' genome. The technology utilizes a combination of biomolecular chemistry methods to eliminate redundant sequences andfluorescence dye assay to identify and isolate these unique sequences.In Phase I, GXI and Dr. Chambers propose to develop and demonstrate the PD technology by identifying unique gene sequences expressed by different cell or tissue types. In Phase II, GXI will develop PD benchtop high throughput system for rapid isolationand identification of unique gene expression profiles. Also included in the Phase II will be a lab-on-chip implementation of the PD technology for a future handheld biosensor application. GXI's Preferential Display is a breakthrough technology which is used to identify unique gene expression sequences of these cellular changes thus providing potentially new age related drug targets to pharmaceutical company end users."