SBIR/STTR Research Award

STTR Phase I: An Advanced Antibiotic Screen of Marine Environmental DNA through a Metabolically Engineered E. coli Strain

Award identifier 395e6b9dfada1d561b22d93f293b5617d0692836ba2f5c1f97e86c8fe0b3befaAwarding agency National Science Foundation

Award amount

$150,000

Program and phase

STTR · Phase I

Award year

2007

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Award details

Awarding agency
National Science Foundation
Branch
Not reported
Recipient company
EarthGenes Pharmaceuticals
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
NSF 06-598
Topic code
BT

Research abstract

This Small Business Technology Transfer (STTR) Phase I research project aims to develop a new method for expressing novel antimicrobials from marine microbial DNA in engineered E. coli. Availability of new antibiotics would be of great value to medicine, as more human pathogens are acquiring resistance to mainstay antibiotic therapy. Moreover, a method for expression and isolation of heterologous natural products in E. coli would also open the door to identification of products with other desired activities, such as anti-tumorigenic compounds.

Technology keywords

Not reported

Agency intelligence

National Science Foundation

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