Specific Action of Docosahexaenoic Acid on Hypertension

Recent studies have suggested that fish oils may have an antihypertensive effect, and several studidone to test these effects using the spontaneously hypertensive rat (SHR) model. These studies haveresults, and there has been no consensus about the mode of action of fish oil on hypertension. One ousing fish oils is the fact that the test material (i.e., the fish oil itself) is not a pure compounmany bioactive fatty acids, including the long chain polyunsaturated fatty acids (LC-PUFAs) EPA andoils also have different concentrations and ratios of these bioactive components. As a consequence,to distinguish cause from effect in dietary supplementation studies with fish oil. For this reason,oils (triglyceride oils which are highly enriched in only a single bioactive component). One such oimicrobially produced triglyceride oil with a DHA enrichment of 40-50% which allows the delivery of oLC-PUFA to the animal without the confounding effects of EPA and other PUFAs found in fish oils. Usiwe will study the effects of including a dietary triglyceride preparation enriched in DHA (the onlythe oil) on hypertension using the SHR model. This should allow us to distinguish the effects of DHAin fish oil. If a significant and reproducible effect is found during Phase I, the objective of thethe efficacy of dietary DHASCO for the reduction of various types of hypertension in controlled clin