SBIR/STTR Research Award

SYNTHESIS OF ANTITUMOR AGENTS RELATED TO FREDERICAMYCIN A

Award identifier 38678e2470b65c96fed35e0ffef03429a80a36e229402a231f7a24abdf77e66eAwarding agency Department of Health and Human Services

Award amount

$50,000

Program and phase

SBIR · Phase I

Award year

1987

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Award details

Awarding agency
Department of Health and Human Services
Branch
Not reported
Recipient company
Merix Corp
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
Not reported

Research abstract

THE OBJECTIVE OF THIS PHASE I PROPOSAL IS TO DISCOVER NOVEL ANTITUMOR AGENTS THAT MAY OFFER THERAPEUTIC ADVANTAGES OVER THOSE CURRENTLY AVAILABLE. THIS RESEARCH PROGRAM WILL BE BASED ON THE CHEMICAL SYNTHESIS OF CERTAIN ANALOGS OF THE ANTITUMOR ANTIBIOTIC FREDERICAMYCIN A. THESE ANALOGS MAY POSSESS GREATER POTENCY, BETTER DRUG DELIVERY PROPERTIES, AND FEWER SIDE EFFECTS THAN THE PARENT NATURAL PRODUCT. IN ADDITION, THE ANALOGS SYNTHESIZED IN THIS STUDY MAY PROVIDE CLUES TO THE BIOCHEMICAL MECHANISM OF ACTION OF FREDERICAMYCIN A.

Technology keywords

Not reported

Agency intelligence

Department of Health and Human Services

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