THIS PROJECT PROPOSES TO DEVELOP AND DEMONSTRATE THE FEASIBILITY OF AN ENZYME IMMUNOASSAY SUITABLE FOR USE FOR PERSONAL MONITORING OF EXPOSURE TO TOXIC AGENTS.

THIS PROJECT PROPOSES TO DEVELOP AND DEMONSTRATE THE FEASIBILITY OF AN ENZYME IMMUNOASSAY SUITABLE FOR USE FOR PERSONAL MONITORING OF EXPOSURE TO TOXIC AGENTS. TECHNIQUESARE PROPOSED WHEREBY IT IS ANTICIPATED THAT TOXIC CHEMICALS CAN BE BOUND DIRECTLY FROM THE VAPOR PHASE ONTO SEMIDRY IMMOBILIZED ANTIBODIES. IT IS FURTHER PROPOSED TO PUT SUCH IMMOBILIZED ANTIBODIES INTO A KIT THAT CAN BE RAPIDLY AND CONVENIENTLY DEVELOPED BY THE USER TO PRODUCE A VISIBLE COLOR IF THE KIT (THEREFORE, THE USER) IS EXPOSED TO THE APPLICABLE TOXIC AGENTS. THE SPECIFIC GOAL OF PHASE I RESEARCH IS TO DEMONSTRATE THE FEASIBILITY OF THIS TECH- NOLOGY FOR DETECTING PARAOXON, AN ORGANOPHOSPHATE INSECTI- CIDE. FURTHER DEVELOPMENT COULD THEN SHOW ITS APPLICABILITYTO OTHER TOXIC AGENTS AND MULTIPLE TOXIC AGENTS. IT IS EXPECTED THAT THIS TECHNOLOGY WILL HAVE BROAD APPLICATIONS AND COULD BE USED FOR MANY VALUABLE COMMERCIAL PRODUCTS.