SBIR/STTR Research Award
ALTERATION OF PROTEIN AFFINITY
Award amount
$100,000Program and phase
SBIR · Phase IAward year
2002Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- PINNACLE PHARMACEUTICALS
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
DESCRIPTION (provided by applicant): The overall goal of this SBIR application is the alteration of protein primary structure in a fashion that permits the control of protein affinity for its target macromolecule(s). The strategy involves the replacement of key protein residues with synthetic amino acids that do not normally occur in ribosomally synthesized proteins. Complexes formed from the modified proteins can be characterized structurally with greater facility, and used to guide the identification of novel drugs.
Technology keywords
Not reported