SBIR/STTR Research Award
AN EFFECTIVE ORAL MALE ANTIFERTILITY AGENT, WHICH IS BOTH NONTOXIC AND REVERSIBLE, IS NOT CURRENTLY AVAILABLE.
Award amount
$50,000Program and phase
SBIR · Phase IAward year
1985Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- H. G. Pars Pharmaceutical Labo
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
AN EFFECTIVE ORAL MALE ANTIFERTILITY AGENT, WHICH IS BOTH NONTOXIC AND REVERSIBLE, IS NOT CURRENTLY AVAILABLE. GOSSYPOL, THE MOST PROMISING NONSTEROIDAL MALE ANTIFERTILITY LEAD, HAS AN UNACCEPTABLY NARROW THERAPEUTIC RATIO. WE PROPOSE THAT THE THERAPEUTIC RATIO MAY BE IMPROVED BY ALTERATION OF THE PHARMACOKINETICS AND BIOAVAILABILITY THROUGH WATER-SOLUBILIZATION. ACCORDINGLY, SEVERAL CAREFULLY CHOSEN WATER-SOLUBLE DERIVATIVES OF GOSSYPOL WILL BE PREPARED. THESE COMPOUNDS WILL THEN BE TESTED FOR BOTH IN VITRO SPERMICIDAL ACTIVITY AND IN VIVO ANTIFERTILITY ACTIVITY. THE IN VIVO TESTS WILL BE EVALUATED BOTH IN TERMS OF EFFICACY AND TOXICITY. THE IDENTIFICATION OF A COMPOUND WITH THE SAME EFFICACY AS GOSSYPOL BUT WITHOUT THE TOXIC EFFECTS WOULD PROVIDE THE BASIS FOR FURTHER STUDY LEADING TO THE EVENTUAL
Technology keywords
Not reported