CARCINOGENESIS INFORMATION FOR ENVIRONMENTAL SUBSTANCES

THE OBJECTIVE OF PHASE I RESEARCH IS TO ESTABLISH THE CARCINOGENESIS INFORMATION DATABASE ENVIRONMENTAL SUBSTANCES(CIDES) AS A PROTOTYPE DATABASE CONTAINING NUMERICAL PROPERTIES DATA FOR ENVIRONMENTAL SUBSTANCES WHICH ARE KNOWNOR THOUGHT TO HAVE CARCINOGENIC PROPERTIES. THE GOAL WILL BE TO PRODUCE A DATABASE WHICH INCLUDES PHYSICAL-CHEMICAL PROPERTY DATA, BOTH POSITIVE AND NEGATIVE SHORT-TERM TEST RESULTS, AND HUMAN AND ANIMAL CARCINOGENESIS DATA. A UNIQUEAIM OF THIS RESEARCH PLAN IS TO APPLY OBJECTIVE CRITERIA TO THE EXPERIMENTAL STUDIES AND DATA IN THE DATABASE IN ORDER TO DERIVE A PAIR OF NUMBERS WHICH RATE: (1) THE PROBABILITYTHAT THE SUBSTANCE IS A CARCINOGEN, AND (2) THE RELIABILITY OF THE TEST RESULTS ON WHICH THAT PROBABILITY IS BASED. THESE TWO RATINGS WILL BE COMBINED INTO A CARCINOGENICITY RATIO WHICH WILL BE APPLIED TO EACH FACTOR. IN ADDITION, EACH PHYSICAL-CHEMICAL DATAPOINT WILL BE CODED WITH A QUALITY INDICATOR WHERE POSSIBLE. RESULTS OF THE PHASE I EFFORT WILL PROVIDE THE BASIS FOR COMPILING AND IMPLEMENTINGAN EVALUATED DATABASE FOR OVER 1000 KNOWN AND POTENTIAL CARCINOGENS DURING PHASE II. THE DATABASE AND ITS ASSOCIA- TED SOFTWARE WILL BE SUITABLE FOR ONLINE SEARCH AND RETRIEVAL AND AS MACHINE-READABLE PRODUCTS FOR RESEARCHERS INTO ONCOLOGIC EFFECTS.