AC Amplifier and System for Nanopore Based DNA Sequencing

The characterization of biologically relevant polymetric materials is a major focus of the bioinstrumentation industry. Of particular interest is the rapid, direct sequencing of DNA through a nanopore as well as the characterization of other biopolymers. Although progress has been made with nanopore sequencing, some fundamental instrumental and system issues have so far kept the method from realizing its potential. Electronic Bio Sciences has already developed a substantially lower noise single channel measurement system that has allowed the measurement of a number of DNA translocation phenomena that have not been previously recorded. Electronic Bio Sciences is proposing to further advance the performance features of the company¿s low noise system by reducing the rate of translocation of DNA through temperature control, integrating AC and DC elements in a single electronics package and increasing the measurement bandwidth of the system. These improvements will provide the tools necessary to advance the state-of-the-art in nanopore sequencing methods and the characterization of biopolymers with nanopores.