SBIR/STTR Research Award
New Method of Ion Dissociation in QTOF Mass Spectrometry
Award amount
$100,000Program and phase
SBIR · Phase IAward year
2003Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- SCIENCE & ENGINEERING SERVICES, INC.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Y7SKZ1CJ5TD1
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
DESCRIPTION (provided by applicant): The main goal of this proposal is to develop a novel method of fragmentation of biomolecules in an electrospray ionization (ESI) quadrupole/time-of-flight mass spectrometer (Q-TOF MS). The new method will enable many more bonds to cleave than a conventional collisionally activated dissociation. It also will preserve labile modifications of the amino acid side chains, such as phosphorylation and glycosylation that facilitates determination of their sites, and can also distinguish between Leucine and Isoleucine amino acid residues. Combined with liquid separation techniques (HPLC,CE) Q-TOF mass spectrometer with a new fragmentation method will provide high-throughput analysis of protein mixtures.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- X-Wind Lidar Profiler
- V-22 Three-Dimensional (3D) Downwash Measurement
- Novel hybrid MS-IMS instrument
- A High-Resolution Differential Mobility Analyzer to Study Biomolecules
- High-resolution Qq-TOF MS instrument
Research funding history
62 SBIR/STTR records share this UEI (1990–2010). Reported award amounts total $13,476,263. Reported amounts are not federal obligations.
Phases: Phase I, Phase II
Agencies: Department of Health and Human Services, Department of Defense, National Aeronautics and Space Administration, National Science Foundation, Department of Commerce