SBIR/STTR Research Award
MULTIFUNCTIONAL SIRNA NANOPARTICLES FOR AML THERAPY
Award amount
$200,000Program and phase
SBIR · Phase IAward year
2010Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- NANOMATERIAL INNOVATION LTD
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- N2KLACCRD6D5
- Solicitation number
- PHS2010-1
- Topic code
- NCI
Research abstract
This project will investigate transferrin (Tf) conjugated fluorescent nanoparticles loaded with an siRNA, LOR-1284, as a theranostic agent for acute myelogenous leukemia (AML). LOR-1284, a siRNA targeting the R2 subunit of ribonucleotide reductase (RNR), is a promising agent for overcoming RNR-mediated drug resistance in AML. The nanoparticles are designed to facilitate LOR-1284 delivery to AML cells (for therapy) while enabling easy detection of delivery efficiency to the AML cells in leukemia patients (for diagnosis). A novel microfluidic method has been developed for nanoparticle synthesis. This project will be carried out by a multidisciplinary team of investigators at NIL and at The Ohio State University.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Molecular Beacons in Lipoplex Nanoparticles for Extracellular Vesicles Based Cancer Diagnosis
- SBIR Phase II: Carbide Bonded Graphene Coating for Enhanced Glass Molding
- SBIR Phase I: Carbide Bonded Graphene Coating for Enhanced Glass Molding
- SBIR Phase I: Low-cost and resuable functional polyaniline for CO2 sequestration and fertilizer production
- SBIR Phase I: Multifunctional NanoPapers for Structural, Wear-Resistant and Conducting Applications
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Mini-reflectance confocal microscope (Mini-RCM) for aiding skin cancer diagnosis and treatment
- Development of small molecule therapeutics targeting AR-V7 for prostate cancer
- Decentralized Clinical Trial of Effectiveness of EnergyPoints App to Guide Acupressure Use for Fatigue and Sleep Disturbances in Cancer Survivors
- Optimized targeted radiotherapy of pancreatic cancer
- Adaptive imaging for pioneering multiplexed spatial profiling of tumors and tissues for cancer research and diagnosis
Research funding history
7 SBIR/STTR records share this UEI (2009–2018). Reported award amounts total $1,613,127. Reported amounts are not federal obligations.
Phases: Phase I, Phase II
Agencies: National Science Foundation, Department of Health and Human Services