SBIR/STTR Research Award

PROINHIBITORS OF CHEMICAL CARCINOGENESIS

Award identifier bff6900e3978d75bb17b5e93c5d6ad653fb30edab9d9974c8b23edab347ebb9dAwarding agency Department of Health and Human Services

Award amount

$50,000

Program and phase

SBIR · Phase I

Award year

1991

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Award details

Awarding agency
Department of Health and Human Services
Branch
Not reported
Recipient company
LKT LABORATORIES, INC.
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
Not reported

Research abstract

THE OVERALL OBJECTIVE OF THIS RESEARCH PROJECT IS TO STUDY CHEMOPREVENTIVE AGENTS THAT ARE DESIGNED TO REACH THE LARGE BOWEL AND PREVENT COLON CANCER. A TOTAL OF EIGHT COMPOUNDS THAT ARE DERIVATIVES OF KNOWN INHIBITORS OF CHEMICAL CARCINOGENESIS WILL BE SYNTHESIZED. THE ABILITY OF THESE PROINHIBITORS TO REACH THE COLON AND THE RATE OF RELEASE OF THE ACTIVE INHIBITORS WILL BE DETERMINED. THE CONCENTRATION OF THE INHIBITORS IN THE COLON CONTENTS AND TISSUES WILL BE ANALYZED. THE INDUCTION OF DETOXIFYING ENZYMES THAT ARE ASSOCIATED WITH THE INHIBITION OF CARCINOGENESIS AS A RESULT OF THE ADMINISTRATION OF PROINHIBITORS WILL BE DETERMINED IN THE LIVER, COLON, AND OTHER TISSUES OF LABORATORY ANIMALS. THE MORTALITY RATE DUE TO COLORECTAL CANCER IN THE UNITED STATES IS SECOND ONLY TO LUNG CANCER. THIS STUDY USES THE PROINHIBITORS CONCEPT TO DESIGN AGENTS THAT ARE AIMED TO PREVENT CANCER OF THE COLON.

Technology keywords

Not reported

Agency intelligence

Department of Health and Human Services

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