TOPIC 368: TREATMENT OPTIMIZATION BY COMBINED A-EMITTER (ARPT)/RADIOTHERAPY (XRT) DOSIMETRY FOR PROSTATE CANCER PATIENTS

We propose to demonstrate a cloud based software service for Combination alpha emitter radiopharmaceutical therapyRPTand external beam radiotherapyXRTCX RPTtreatment planningBoth modalities deliver radiationWe will demonstrate feasibility clinically by collecting the data needed from an existing Hopkins trial evaluating combination XRT with XofigoRa dichlorideanRPT that concentratesparticle radiation to prostate cancer bone metastasesBypiggybackingon this trial we will evaluate the dosimetry technology for CX RPT that we propose to develop and commercialize without having to cover the costs of the entire trialObjectiveVia the studies proposed and data collecteddemonstrateretrospectivelythatof the patients would have benefitted from an adjustment in their XRT treatment plan to meet tumor dose criteria while respecting organ dose constraintsObjectiveImplement the CX RPT enabling softwareD RD Xin a web cloud system as a prototype for a future software service add on to existingD XRT treatment planning systemsObjectiveValidateD RD X against RPTDoseour Phase I proof of concept prototypeThe work proposed will enable a treatment planning based combination treatment of XRT andRPT using cloud based softwareThis will improve patient care by reducing the empiricism typical of chemo XRT combination therapy and demonstrate the efficacy of a cloud based system for performing the treatment planning