Salmon clotting proteins for human bandages

Not Available "Fibrin bandages have shown considerable promise in controlling majorblood loss. However, two significant problems are cost, and thepossibility of infectious agents.Our overall objective is to solve both problems with the use offibrinogen and thrombin from salmon plasma. Phase I aims are: 1. Toprepare a viral-inactivated, stable, salmon fibrinogen and thrombin; and2. To characterize this material.Salmon clotting proteins are compatible with human proteins, and areless likely to be expensive due to the large untapped blood supply fromfarmed salmon. They offer safety from mammalian infectious agents,especially prions, due to the evolutionary distance between fish andmammals, and the low body temperature of these fish.We propose to develop viral-inactivation methods by spiking the salmonproteins with salmon viruses, and then determining virus titer afterlyophilization and heating. The virus-inactivated proteins will be usedfor stability studies that measure identity, purity, and potency, withand without additives, after defined storage conditions.Characterization studies of the salmon proteins will determine possibleadvantages over mammalian proteins.Salmon clotting proteins offer an effective, innovative, material forhuman use that is likely to be safer and less costly than humanproteins. The anticipated benefits of the proposed work is a safer, less -costlyfibrin bandage."