SBIR/STTR Research Award
Diagnostics to enable malaria and neglected tropical diseases
Award amount
$225,000Program and phase
SBIR · Phase IAward year
2018Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- NANOCOMPOSIX, INC.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- EVQMBF7KC8P3
- Solicitation number
- Not reported
- Topic code
- NIAID
Research abstract
Onchocerciasis affectsmillion people worldwidepredominantly in sub Sahara Africaand is a major cause of irreversible blindness among adultswith serious socioeconomic consequencesThe proposal s objective is to develop a simple and inexpensive rapid diagnostic testRDTto detect the presence of two already identified onchocerciasis specific antigens from a finger stick blood sampleThe proposal combines three innovationsaNovel antigens currently provide asensitivity andspecificity when analyzed by ELISAThis is the first time that clinically relevant Ovolvulus antigens have been identifiedbGold nanoshells will be utilized as novel high contrast reporter particles to provide an ultra sensitive assaycA companion smartphone reader will quantify the amounts of antigens present in the sampleand capture GPS coordinates and a time stamp for real time spatial analysisContractor proposes to deliver a diagnostic via the following pursuitsAimSource key reagentsincluding antigensantibodiesand nanoparticlesAimIdentify optimal lateral flow assayLFAconfigurationAimDevelop two monoplexed LFAsone for each antigenand AimDeliver a biplexed LFAThe performance of the Phase I devicesensitivityspecificitywill be evaluated with overOnchocerca positive andOnchocerca negative preserved serum samples
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Obscurant Material Drying Processes
- THE OBJECTIVE OF THIS CONTRACT IS TO DESIGN AND SYNTHESIS A NEW PLGA BASED NANOPARTICLE WITH NANOPARTICLE WITH OPTIMAL PROTEIN-ADJUVANT FORMULATION CO
- A point of care test for TB antibiotic concentration in blood
- Rapid diagnostic to determine CMV serological status
- New Carriers Used as Adjuvants for Controlled HIV Immunogen Delivery into Targeted Antigen Presenting Cells
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Manufacturing and Formulation Process Development for a Prophylactic Cholera Phage Cocktail
- A first-in-class product for the clearance of high-risk human papillomaviruses
- A Rapid, Point-of-Care Diagnostic to Identify Viable Sexually Transmitted Infections, Reduce Overtreatment, and Prevent Emerging Antibiotic Resistance
- Optimization, Pharmacokinetics, and Efficacy of an IgG Protease for the Treatment of Immune Thrombocytopenia and Other IgG-Mediated Autoimmune Diseases
- Nebulized ALX1 as a treatment for Pseudomonas aeruginosa infections in bronchiectasis patients
Research funding history
50 SBIR/STTR records share this UEI (2005–2020). Reported award amounts total $19,180,547. Reported amounts are not federal obligations.
Phases: Phase I, Phase II
Agencies: Department of Defense, Department of Health and Human Services, National Science Foundation, National Aeronautics and Space Administration