SBIR/STTR Research Award
CHOLECYSTOKININ ANTAGONISTS
Award amount
$50,000Program and phase
SBIR · Phase IAward year
1990Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- Peptide Technolgies Corp.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
POSSIBLE THERAPEUTICS FOR NEUROENDOCRINE AND GASTROINTESTINAL TUMORS AND NEUROPSYCHIATRIC DISEASES MAY BE DEVELOPED FROM PEPTIDE ANTAGONISTS OF THE CENTRAL NERVOUSSYSTEM CHOLECYSTOKININ RECEPTOR. STRUCTURALLY MODIFIED CHOLECYSTOKININ OCTAPEPTIDE FRAGMENTS WILL BE TESTED FOR INTERACTION WITH CHOLECYSTOKININ RECEPTORS IN A NEUROENDOCRINE CELL LINE, HUMAN SMALL-CELL LUNG CARCINOMA. THESE COMPOUNDS, MORE CLOSELY RESEMBLING NATURALLY OCCURRINGNEUROPEPTIDES, SHOULD CROSS-REACT LESS WITH OTHER CENTRAL NERVOUS SYSTEM RECEPTORS, RESULTING IN FEWER UNDESIRABLE SIDE EFFECTS. POTENT COMPOUNDS IDENTIFIED IN THE CELL ASSAYWILL BE FURTHER EVALUATED IN PHARMACOLOGICAL PRECLINICAL STUDIES IN THE PHASE II RESEARCH.
Technology keywords
Not reported