SBIR/STTR Research Award

THEIR POTENTIAL APPLICATIONS TO A SUBUNIT VACCINE

Award identifier bff245a614951f0480a0bd2f7b273c67d64c5d4be234af2f8b1f5eba60a94f1aAwarding agency Department of Health and Human Services

Award amount

$50,000

Program and phase

SBIR · Phase I

Award year

1986

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Award details

Awarding agency
Department of Health and Human Services
Branch
Not reported
Recipient company
NEUGENESIS CORPORATION
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
Not reported

Research abstract

HUMAN T-CELL LYMPHOTROPHIC VIRUS TYPE I (HTLV-I) IS THE CAUSATIVE AGENT OF AN AGGRESSIVE FORM OF T-CELL LEUKEMIA ENDEMIC TO CERTAIN GEOGRAPHIC AREAS BUT ALSO CURRENTLY INCREASING IN FREQUENCY IN THE SAME POPULATION AT RISK FOR DEVELOPING AIDS. SERO-EPIDEMIOLOGIC DATA SUGGEST THE PRESENCE OF A TYPE-COMMON NEUTRALIZATION DETERMINANT. THIS PROPOSAL SEEKS TO IDENTIFY AND PRODUCE, BY USE OF A RECOMBINANT DNA EXPRESSION SYSTEM, HTLV-I ENCODED EPITOPES TO ASSESS THEIR EFFECT ON IN VITRO MEASURES OF INFECTIVITY AND VIRUS NEUTRALIZATION. IMMUNOREACTIVE EPITOPES CHARACTERIZED IN THIS MANNER HAVE POTENTIAL APPLICATION TO EVENTUAL PRODUCTION OF AN HTLV-I SUBUNIT VACCINE.

Technology keywords

Not reported

Agency intelligence

Department of Health and Human Services

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