STUDY OF EXERCISE PERFORMANCE USING 31P NMR AND AN ISOKINETIC ERGOMETER

PHOSPHO-ENERGETICS, INC. (P-E) HAS DEVELOPED AN NMR SPECTRO-METER FOR THE VALIDATION OF 31P IN DISEASED AND NORMAL HUMANTISSUES; BASED UPON THAT PROCESS, P-E HAS NOW DEVELOPED A COMBINATION NMR/WORK OUTPUT MEASURING INSTRUMENT. STUDIES HAVE BEEN PERFORMED WITH SUBJECTS SUFFERING FROM PERIPHERAL VASCULAR DISEASE, GENETIC DEFECTS, AND CARDIOMYOPATHY, AS WELL AS NORMAL VOLUNTEERS AND ATHLETES LEADING TO A DATABASEFROM WHICH THE RATIOS OF VARIOUS PHOSPHATES, E.G., PHOSPHO- CREATINE/INORGANIC PHOSPHATE (PCR/PI), PHOSPHO DIESTERS/PI, AND SUGAR PHOSPHATES/PI, MAY BE USED TO DETERMINE THE STATE OF THE TISSUE. IT IS PROPOSED TO EXTEND THIS WORK INTO A STUDY OF "APPARENT" NORMAL VOLUNTEERS BETWEEN THE AGES OF 65AND 75 TO TRY AND CORRELATE THE EXISTING DATA WITH ONGOING MEASUREMENTS RELATIVE TO AN EXERCISE PROTOCOL AND NUTRITION-AL PROTOCOL. TO DO THIS, P-E MUST DEVELOP A NEW, NONMAGNET-IC LINKAGE SUITABLE FOR IN-MAGNET LEG EXERCISE. IT IS EXPECTED THAT THE COMBINED 31P NMR, NON-MAGNETIC LINKAGE ANDERGOMETER COULD BECOME COMMERCIALLY IMPORTANT AS A SCREENINGTEST (1) TO IDENTIFY INCIPIENT PVD OR DIABETES AND (2) TO EVALUATE THE EFFECT OF EXERCISE AND THE RELATIONSHIP BETWEENEXERCISE AND NUTRITION IN THE AGING POPULATION.