LIGANDOLIPOSOME BASED GENE DELIVERY FOR CANCER THERAPY

Not Available A corrosion protection process for treating structural aluminum aircraft components is proposed which can simplify manufacturing and maintenance operations while dramatically reducing hazardous waste generation. The proposed research explores the feasibility of using an aqueous blend of surface oxide derivatizers and film-forming polymers with non-hazardous corrosion inhibitors to yield self-adherent, self-priming topcoats. The proposed primer/topcoat paint would exhibit better stability in the presence of inorganic corrosion inhibitors and yield coatings having significantly less permeability to water and ionic species than conventional waterborne coatings. The ability to form strongly adhered, durable barrier layers over structural metal alloys without the need for toxic chemical etchants and pigments or multiple coating applications would represent a significant advancement in corrosion engineering. The objective of the Phase I program is to identify candidate materials which meet the goals of low toxicity, simple application, adhesion promotion, and corrosion prevention. A novel combination of polymers and sol-gel precursors will be used to form stratified coatings to achieve optimum adhesion and corrosion inhibition. These formulations will be tested on common aircraft aluminum alloys for salt fog resistance and paint adhesion. Potentiodynamic electrochemical analysis will also be used to study the corrosion inhibiting mechanisms.