Combined Extinction/Flourescence Absorption Diagnostics for Pharmaceutical Sprays

This Phase I project will evaluate the feasibility of a pharmaceutical spray quality audit system. The spray quality audit system will estimate the mass distribution of active ingredients and droplet sizes in pharmaceutical sprays using combined fluorescence absorption and light extinction tomography. En’Urga will modify an existing instrument to simultaneously obtain full volume fluorescence absorption and light extinction in a spray containing a fluorophore. The existing user interface will be modified to calculate the full planar mass distribution of active ingredients in the plane as well as the planar drop sizes. The results will be validated using conventional methods.