Biodegradable Polylactide-Co Glycolide Medical Cements

Osteomyelitis is a serious orthopedic problem, and its prevention or treatment using systemic antibcomplications and is often unsuccessful. The use of polymethylmethacrylate beads or bone cement to dto bone sites does reduce the incidence of post- operative bone infections, but these non-porous poldrug delivery vehicles, and because they are non-biodegradable materials they cannot be used where bdesired. BIOTEK has recently discovered new methods which for the first time allow medical cements tporous, biodegradable, FDA-approved polylactide- coglycolide. These new cements are produced using hand sintering agents, and their workability, cure time, shrinkage, porosity, and strength are subjecprepare and characterize biodegradable cements for use in bone cavities, introduce a prototype antibdemonstrate sustained drug delivery in vitro, and test the most promising formulation in vivo in a r