SBIR/STTR Research Award

Synthesis of Cyclic ADP Ribose

Award identifier f3c0ea86df8ad049ddf423f7954977b361d49ce223a46de5455dbf6fa5cdfeddAwarding agency Department of Health and Human Services

Award amount

$79,700

Program and phase

SBIR · Phase I

Award year

1995

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Award details

Awarding agency
Department of Health and Human Services
Branch
Not reported
Recipient company
Research Biochemicals,
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
Not reported

Research abstract

We will develop the total synthesis of cyclic adenosine diphosphate ribose (cADPR). We envision a csynthesis in which the morpholine- activated phosphoroamidate N,N'-dicyclohexylcarboxamidine salt of'phosphate is coupled to 2,3,5-tri-O-benzoyl-D-ribose. The protecting groups will be removed and thecyclized to produce the desired final product, cADPR. The synthetic material will be fully characterto enzymatically prepared cADPR.

Technology keywords

Not reported

Agency intelligence

Department of Health and Human Services

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