SBIR/STTR Research Award
DEVELOPMENT OF A NONSURFACTANT FORMULATION FOR INDUCING AGENTS
Award amount
$318,778Program and phase
SBIR · Phase IIAward year
1992Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- Pharmos Corporation
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
ADVERSE REACTIONS HAVE BEEN REPORTED TO OCCUR AFTER ADMINISTRATION OF COMPOUNDS SOLUBILIZED IN AQUEOUS VEHICLES. THESE SIDE EFFECTS MAY BE REDUCED OR ELIMINATED BY COMBINING THE PRIMARY INDUCING AGENT, ALFAXALONE, WITH CYCLODEXTRINS, WHICH HAVE BEEN SHOWN TO IMPROVE SOLUBILITY AND EFFICACY OF OTHER STEROIDS. PRELIMINARY STUDIES IN A RAT MODEL SHOW PROMISE FOR THIS COMBINATION. SUCCESSFUL DEVELOPMENT OF THIS TECHNIQUE WILL PROVIDE A SAFE ALTERNATIVE FOR A NONSURFACTANT FORMULATION FOR THE INDUCINGAGENT, REDUCING TOXIC SIDE EFFECTS AND ALLOWING SAFE AND RELIABLE ANESTHESIA.
Technology keywords
Not reported