SBIR/STTR Research Award
JEFFERIES ASSOCIATES WISHES TO APPLY ITS PROPRIETARY STABILIZATION TECHNOLOGY TO THE PROBLEM OF RAPID LIPOSOME UPTAKE BY THE RES.
Award amount
$48,500Program and phase
SBIR · Phase IAward year
1985Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- Jefferies Associates
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
JEFFERIES ASSOCIATES WISHES TO APPLY ITS PROPRIETARY STABILIZATION TECHNOLOGY TO THE PROBLEM OF RAPID LIPOSOME UPTAKE BY THE RES. WE BELIEVE THAT, WITH PROPER SURFACE MODIFICATION OF THE LIPOSOME MICROCARRIER, UTILIZING SURFACE BINDING OF A SPECIFIC MEMBRANE-BOUND GLYCOPROTEIN, THE CIRCULATORY HALF-LIFE OF INJECTABLE LIPOSOMES CAN BE INCREASED SIGNIFICANTLY. THIS HYPOTHESIS WILL BE TESTED BY IN VITRO MACROPHAGE UPTAKE OF ALTERED LIPOSOMES AND A DIRECT COMPARISON TO CONTROL PHOSPHOLIPID VESICLES.
Technology keywords
Not reported