SBIR/STTR Research Award

STABILIZATION OF PROTEINS BY CROSSLINKING

Award identifier 5df17c1604ddaa7953e349ea76f5b5314878707c1921db5a03476329446832f6Awarding agency Department of Defense · Army

Award amount

$161,000

Program and phase

SBIR · Phase II

Award year

1986

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Award details

Awarding agency
Department of Defense
Branch
Army
Recipient company
SURMODICS, INC.
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
Not reported

Research abstract

A PROJECT IS PROPOSED TO DEVELOP TECHNIQUES FOR STABILIZATION OF PROTEINS BY COVALENT CROSSLINKING. WE PLAN TO USE MONOCLONAL ANTIBODY SPECIFIC FOR T-2 TOXIN AS THE PRIMARY PROTEIN TO USE FOR DEVELOPING STABILIZATION TECHNOLOGY. USING LIGAND STABILIZATION TO DECREASE INACTIVATION DURING THE CROSSLINKING, WE PROPOSE TO EVALUATE THE EFFECTIVENESS OF INTRAMOLECULAR CROSSLINKING BETWEEN BOTH HYDROPHILIC AND HYDROPHOBIC GROUPS IN THE PROTEIN MOLECULES AS WELL AS INTERMOLECULAR CROSSLINKING WITH HIGHLY STRESS RESISTANT PROTEIN.

Technology keywords

Not reported

Agency intelligence

Department of Defense

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