SBIR/STTR Research Award
THE GLYCOPROTEIN HORMONE ERYTHROPOIETIN IS A PRIME REGULATOR OF RED CELL PRODUCTION IN HIGHER ORGANISMS.
Award amount
$50,000Program and phase
SBIR · Phase IAward year
1985Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- Hybridoma Sciences Inc.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
THE GLYCOPROTEIN HORMONE ERYTHROPOIETIN IS A PRIME REGULATOR OF RED CELL PRODUCTION IN HIGHER ORGANISMS. THE HORMONE IS PRODUCED IN THE KIDNEY IN RESPONSE TO HYPOXIA, FOR EXAMPLE, AS A RESULT OF ANEMIA. IT WOULD BE OF GREAT VALUE TO HAVE AN IMMUNOASSAY TO MONITOR ERYTHROPOIETIN LEVELS IN PEOPLE SUFFERING FROM ANEMIA, PULMONARY INSUFFICIENCY, RENAL TUMORS, ETC. AT PRESENT, ALTHOUGH BOTH MONOCLONAL ANTIBODIES AND POLYCLONAL ANTIBODIES HAVE BEEN RAISED TO ERYTHROPOIETIN, NO EFFICIENT IMMUNOASSAY BASED UPON THE (PREFERRED) MONOCLONAL ANTIBODY TECHNOLOGY HAS BEEN DEVELOPED. THE SPECIFIC AIM OF THIS PROPOSAL IS TO DEVELOP A PANEL OF MONOCLONAL ANTIBODIES TO ERYTHROPOIETIN, TO BE USED IN THE DESIGN OF AN IMMUNOASSAY APPROPRIATE TO THE CLINICAL LABORATORY.
Technology keywords
Not reported