SBIR/STTR Research Award
RADIOLABELED ANTIBODY DELIVERY SYSTEM QUALITY CONTROL
Award amount
$482,000Program and phase
SBIR · Phase IIAward year
1989Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- Rhomed, Inc.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
A QUALITY CONTROL (QC) TEST KIT WILL BE DEVELOPED AND AND VALIDATED FOR USE IN MEASURING THE PERCENTAGE OF IMMUNOREACTIVE RADIOACTIVITY OF RADIOLABELED ANTIBODY OR ANTIBODY FRAGMENTS INTENDED FOR PATIENT USE. THIS QC PRODUCT IS BEING DESIGNED FOR A MULTICENTERED CLINICAL TRIALOF COMPOUNDED, RADIOLABELED ANTIBODIES. PANELS OF CURRENTLYAVAILABLE MONOCLONAL ANTIBODIES (MABS) THAT HAVE POTENTIAL FOR TARGETING DRUGS AND RADIOISOTOPES TO TUMORS WILL BE SELECTED FOR INCLUSION IN THE CLINICAL TRIAL. THIS PRODUCT WILL BE USED IN AN ANTIBODY DELIVERY SYSTEM, WHICH WILL EMPLOY A MONOCLONAL ANTIBODY/TUMOR-ASSOCIATED ANTIGEN (MAB/TAA) MATCHING KIT TO SELECT ANTIBODIES FOR USE IN INDIVIDUAL PATIENTS. THE QC TEST RESULTS WILL BE USED TO DETERMINE ACCEPTABILITY OF THE COMPOUNDED DRUG FOR PATIENT USE AND FOR POOLING OF DATA FROM DIFFERENT INSTITUTIONS.
Technology keywords
Not reported