Novel Treatment for Myocardial Disorders

Coronary artery disease is the leading cause of death in the United States. Approximately300,000 bypass grafts are performed annually. With this statistic in mind it is obvious that a more costeffective, less invasive system has to be developed. We have developed and patented an UltrasonicAngioplasty system that is capable of dissolution of plaque and thrombus. We will examine anenhancement of this device by combining microwave antennas inside the catheter and examine thefeasibility of a system for all disease ablation. The specific aims are (1) development of a microwaveantenna/catheter- to enhance or supplement the existing Ultrasonic device, (2) examine the feasibilityof using the device in the treatment of arrhythmias and tachycardia. Preliminary simulations andexperimental work have been encouraging. Focussed energy and selectivity are possible. particularlyin the diseased vessel.