SBIR/STTR Research Award
FOCUSED DIVERSITY--INHIBITORS OF HIV MULTIPLICATION
Award amount
$100,000Program and phase
SBIR · Phase IAward year
1997Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- METAPHORE PHARMACEUTICALS, INC.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
The focus of this proposal is development of solid phase technology for the synthesis of combinatorial libraries of bicyclams. Some members of this class have been showed to be very potent inhibitors of HIV (human immunodeficiency virus) multiplication with very low cellular toxicity. By lead optimization, compounds with enhanced potency and improved bioavailability may be discovered in which toxic side effects of metal complexation associated with this class of compound may be alleviated. Metal affinity will be determined by novel high throughput screens and anti-HIV activity will be determined in cellular assays.
Technology keywords
Not reported