Thrombin Peptide Effect of Cellular Antimicrobial Action

Growth factor technology may be beneficial in wound management, but many growth factors have littlerecruitment or activation of inflammatory cells. Thus, these factors may have minimal efficacy in coThrombin is a natural early initiator of cellular responses to injury causing vascular changes and ceffects on inflammatory cells. A single topical application of thrombin or synthetic thrombin recept(TRAP-508) accelerates healing of surgical incisions by up to 80 percent (1,2), and enhances closure100 percent relative to controls (3). Histology indicates an early transient accumulation of inflammtreated wounds suggesting possible efficacy in reducing wound infection. The potential of TRAP-508 tantimicrobial effects will be determined using 1) polyvinyl alcohol(PVA) sponge implants with or witrats with controlled infections, 2) assessment of in vitro and in vivo bactericidal activity of cell3) analysis of TRAP-508 activation of neutrophils to release superoxides and myeloperoxidase into wostudies will determine the potential for development of TRAP-508 products to accelerate healing andacute and chronic wounds.