Pd-128,907 Based Dopamine D3 Receptor Fluorescent Probes

Fluorescently amended analogs of the autoreceptor selective agonist PD- 128,907 will be synthesizedfunctionalization through suitable spacer units at ring amended nitrogen followed by coupling with fHigh enantiomeric excesses for all targets will be achieved either by classical resolution or througsynthesis of a late-stage intermediate common to both approaches. The affinity of each compound forthen be determined at NovaScreen using their standard protocol. Suitably selective candidates will thouse on an IDEXX Fluorescence Concentration Analyzer, an instrument capable of measuring bound ligaestablishing its fluorescence profile.