SBIR/STTR Research Award
Brain Cancer Xenotransplant Model for Drug Screening
Award amount
$191,984Program and phase
SBIR · Phase IAward year
2010Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- PHYLONIX PHARMACEUTICALS, INC.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- PHS2010-2
- Topic code
- NCI
Research abstract
DESCRIPTION (provided by applicant): In this research, we will develop zebrafish as a new xenotransplant animal model to assess brain cancer progression and identify potential drug candidates. Brain cancer accounts for approximately 10 - 30% of adult cancers and many forms of cancer can metastasize to the brain. Although immunodeficient mice and rats have played an important role as hosts for brain cancer xenografts, a simple and cost-effective orthotopic brain cancer model is required for more efficient in vivo cancer drug screening. PUBLIC HEALTH RELEVANCE: In this research, we propose to develop zebrafish as a new xenotransplant animal model to assess brain cancer progression, identify potential drug candidates, and rank efficacy.
Technology keywords
Not reported
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