ANTISENSE THERAPY USING NOVEL RNA MIMETICS

Not Available We propose to conduct research to demonstrate in a high power density diesel engine the feasibility of controlled combustion by regulating the excitation of the singlet delta level of the oxygen in the charge air entering the engine. In this work, the temperature will be controlled in the charge air into the engines as an element of an integrated precise control of the combustion process. The air mass flow and the fuel injection rates will be adjustable to obtain desired power level within the constraints of engine structural strength, thermal flows, and the production of particulates and other exhaust emissions. The test engine will be a supercharged/turbocharged uniflow 2 cycle diesel engine with high pressure common rail fuel injection. In Phase I, we shall research technologies and concept designs shall be presented and substantiated via analytical calculations and modeling, virtual prototyping, drawings and a very limited engine bench-type testing demonstration. In Phase I Option we shall prove concepts from a feasibility standpoint with modeling and bench testing. In Phase II, the concept shall be demonstrated using a single or a multi-cylinder engine with operating conditions of the target high output military engine. BENEFITS: Our efforts will develop a very high power density diesel engine with an integrated control strategy which will improve combustion throughout the duty cycle, particularly at idle and low part load; the benefits include increased fuel ec