SBIR/STTR Research Award
LARGE-SCALE PRODUCTION OF THERAPEUTIC OLIGONUCLEOTIDES
Award amount
$463,306Program and phase
SBIR · Phase IIAward year
1991Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- Glen Research Corp.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
RECENT ACTIVITY HAS INDICATED THE TREMENDOUS POTENTIAL OF ANTISENSE OLIGONUCLEOTIDES IN A VARIETY OF RESEARCH ENVIRONMENTS. OF PARTICULAR INTEREST HAS BEEN THE DEMONSTRATION THAT ANTISENSE OLIGONUCLEOTIDES WITH A MODIFIED PHOSPHATE BACKBONE HAVE SIGNIFICANT ACTIVITY AGAINST THE AIDS VIRUS. ONCE A SUITABLY ACTIVE ANTISENSE OLIGONUCLEOTIDE IS IDENTIFIED, THERE WILL LIKELY BE SIGNIFICANT DELAYS IN ITS COMMERCIAL DEVELOPMENT BECAUSE OF TECHNICAL PROBLEMS IN ITS PRODUCTION ON A LARGE SCALE. THE CURRENT RESEARCH PLAN IS DESIGNED TO LEAD TO THE DEVELOPMENT OF A SYNTHESIS SYSTEM CAPABLE OF BEING ADAPTED TO A PHARMACEUTICAL PRODUCTION SCALE.
Technology keywords
Not reported