SBIR/STTR Research Award
THERAPY FOR THALASSEMIA
Award amount
$50,000Program and phase
SBIR · Phase IAward year
1987Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- Biosym Technologies Inc.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
THE OVERALL OBJECTIVE OF THIS PROPOSED PROJECT IS TO EXTEND RECEPTOR-BASED DRUG DESIGN TO INCLUDE THE USE OF MODERN, STATE-OF-THE-ART SIMULATION OF THE STRUCTURE, ENERGETICS, AND DYNAMICS OF PROTEIN-PROTEIN AND PROTEIN-LIGAND INTERACTIONS. IN PARTICULAR, BIOSYM TECHNOLOGIES, INC. PROPOSES TO USE THESE TECHNIQUES TO MODEL AN ALPHA-HEMOGLOBIN TETRAMER AND TO USE INFORMATION OBTAINED FROM THESE STUDIES FOR DESIGNING LIGANDS THAT STABILIZE SUCH OXYGEN CARRIER ALPHATETRAMERS. THE RESULTING LIGANDS COULD ULTIMATELY BE USED IN THE TREATMENT OF BETA THALASSEMIA.
Technology keywords
Not reported