DESIGN AND CONSTRUCTION OF A 3.

DESIGN AND CONSTRUCTION OF A 3.0 TESLA HIGH-RESOLUTION SUPERCONDUCTING MAGNET SYSTEM WITH SHORT HORIZONTAL 30CM BORE TO INCORPORATE WITH PHOSPHO-ENERGETICS, PRELIMINARY WORK HAS BEEN PERFORMED AT THE UNIVERSITY OF PENNSYLVANIA DEPARTMENT OF BIOCHEMISTRY USING 1.5 AND 1.9 TESLA SUPERCONDUCTING MAGNETS FOR A VARIETY OF IN VIVO STUDIES OF VARIOUS DISEASES IN ANIMAL MODEL AND HUMANS. RELEVANT TO THIS PROPOSAL ARE STUDIES ON ANIMAL MODEL TUMORS AND THERAPY TO FOLLOW THEIR TIME COURSES NONINVASIVELY. IN ADDITION, NEUROBLASTOMA TUMORS OF THE LIVER HAVE BEEN STUDIED IN INFANTS AND UNLIKE 1H NMR IMAGING, WHICH YIELDS ANATOMICAL DATA WITH LIMITED SPECIFICITY, 31P NMR YIELDS DIRECT MEASUREMENT OF METABOLISM THAT PRECEDES ANATOMICAL CHANGES. UNFORTUNATELY, 31P IS PRESENT IN VERY LOW CONCENTRATIONS, 1020MM COMPARED TO PROTONS AT 100M, AND IS THEREFORE MUCH MORE DIFFICULT TO DETECT. P-E HAS PIONEERED, THROUGH ITS INTERACTION WITH THE GROUP LED BY DR. BRITTON CHANCE AT THE DEPARTMENT OF BIOCHEMISTRY, UNIVERSITY OF PENNSYLVANIA, IN THE APPLICATION OF 31P NMR INSTRUMENTATION TO IN VIVO MEASUREMENTS OF VARIOUS METABOLIC DISORDERS. MORE RECENTLY, HIGH-RESOLUTION PROTON NMR, WHERE THE BULK WATER SIGNAL IS SUPPRESSED YIELDING UNDERLYING HIGH-RESOLUTION SPECTRA OF THE SAME PHOSPHOROUS METABOLITES PLUS LACTATE, HAS INDICATED THAT OBSERVATION OF 31P AND HIGH-RESOLUTION 1H WOULD YIELD